Packing Cubes, Organizer Pouches, Key Straps... there's myriad of ways to customize the interior organization of the Synapse 19 backpack. Here's just one example of which accessories fit where:

Bottom exterior pocket: 3D Mesh (3D Clear or Dyneema/nylon would also fit) Organizer Cube in Steel Dyneema/nylon, tethered with a Key Strap in Wasabi Dyneema/nylon.

Left exterior front pocket: Pocket Pouch, Utility Strap in 14".

Right exterior front pocket: Mini Clear Organizer Pouch and the included Key Strap, Black, in 8".

Top exterior pocket: Nothing. As you can see, it's zippered shut. It's small enough that you might not need further organization. That said, you could fit a Pocket Pouch here or add an 8" Key or Utility Strap to tether your keys, flashlight, knife, or other small items.

Exterior water bottle pocket: Travel Stuff Sack, Size 2, in Iberian.

Main compartment: Two Tri-Star Medium Packing Cubes would fit, but we chose instead to use one Tri-Star Medium Packing Cube, one Tri-Star Small Packing Cube, and a Travel Stuff Sack, Size 2, in Wasabi. We liked how the Travel Stuff Sack fit nicely on the other side of the Tri-Star Small Packing Cube. Yet another option would be one Tri-Star Medium Packing Cube and two Clear Quarter Packing Cubes (one in front of the other). And don't forget the open-top pocket inside of the main compartment of the Synapse 19: put your tablet (in a case or sleeve) here, or a Medium Organizer Pouch. Last but not least, there's a 3D Clear Organizer Cube in Black, tethered with a Key Strap in Wasabi, that'll fit/rest on top of the Packing Cubes.